EEG discharges and motor seizures induced by hippocampal kindling. A, afterdischarges recorded from a mouse after the first stimulation (top) and fully kindled following an intra-peritoneal injection of saline (middle) or midazolam (MDZ; 2 mg/kg, bottom). The afterdischarges were evoked by unilateral CA3 stimulation (60 Hz for 2 seconds, indicated arrows) and recorded from the contralateral CA3 area. B, seizure stages assessed from 6 animals. *, p = 0.008 or p = 0.014; Wilcoxon signed rank test. C, afterdischarges measured from same 6 animals. *, p = 0.014; paired t tests.
Jeffrey et al. BMC Neuroscience 2013 14:82 doi:10.1186/1471-2202-14-82