Time taken for the “T-turn” in the pole test. To observe behavioral changes in wild-type and D3 receptor-deficient mice treated with MPTP, wild-type mice injected with saline, wild-type mice injected with MPTP, D3 receptor-deficient mice injected with saline, and D3 receptor-deficient mice injected with MPTP were subjected to the pole test. All animals were trained three times before performing the test. The time from when the animals were positioned head-upward near the top of the pole until they turned completely downward was recorded and calculated as the mean±SEM. P < 0.05 was considered statistically significant. MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NS, normal saline.
Chen et al. BMC Neuroscience 2013 14:76 doi:10.1186/1471-2202-14-76