The PVD sensory neurons mediate the thermal noxious response in the midbody and tail. Worms with laser ablated PVD neurons (left column) show statistically significant defective thermal avoidance behavior compared to mock ablated worms when stimulated in the midbody and tail (Kruskal-Wallis test, Dunn’s multiple comparison p < 0.001); the head response is similar to the mock ablation result. N = 9 ablated worms, N = 62 total experiments. ser-2prom3:DEG-3-N293I worms have genetically ablated PVD neurons (right column), and show severe defects in the noxious thermal response for the midbody and tail compared to N2 (Kruskal-Wallis test, Dunn’s multiple comparison p < 0.0001). The head response is unaffected. N > 12 for each region. Top row: head, middle row: midbody, bottom row: tail.
Mohammadi et al. BMC Neuroscience 2013 14:66 doi:10.1186/1471-2202-14-66