HFS delivered to the VTA suppressed nociceptive responses recorded in the PFC. A: Time course of procedure is presented. Pre: Pre-HFS. B: The top trace represents ECoG. The second trace is multiple unit discharges. The bottom trace represents a pressure curve. Nociceptive responses were depressed by HFS delivered to the VTA at 10min. At 60 min after HFS, nociceptive responses recovered to the pre-HFS control level. C, D: Inhibitory effects of VTA on nociceptive responses induced by HFS delivered to the VTA. Mean changes in the duration (C) and frequency (D) of responses are presented. **p<0.01, Error bars represent S.E. n=11.
Sogabe et al. BMC Neuroscience 2013 14:65 doi:10.1186/1471-2202-14-65