More polysynaptic GABAergic inputs are evoked after cortical stimulation. A: A dSPN corticostriatal response before (red trace) and after the GABAA-receptors antagonist, 10 μM bicuculline (black trace), were added to the bath saline. B: Similar experiment in the same dSPN but using intrastriatal stimulation. Bicuculline reduced both responses. C, D: subtraction of responses in A and B: bicuculline reduced the responses in both cases. Both responses exhibit hyperpolarizing and depolarizing phases (with respect to firing threshold). E: A iSPN corticostriatal response before (green trace) and after 10 μM bicuculline (black trace). F: Similar experiment in the same iSPN but using intrastriatal stimulation. Bicuculline enhanced both responses. G, H: subtraction of responses in E and F: both responses exhibit hyperpolarizing actions (with respect to firing threshold).
Vizcarra-Chacón et al. BMC Neuroscience 2013 14:60 doi:10.1186/1471-2202-14-60