Table 4

Permeability of CNS and non-CNS crossing small molecules across RBEC and RSCEC monolayers grown on Millipore cell culture inserts
RBECs RSCECs
Passive transport into CNS? Number of inserts Mean Pe (×10-6cm/sec) SEM (×10-6cm/sec) Number of inserts Mean Pe (×10-6cm/sec) SEM (×10-6cm/sec)
Atenolol No 15 16.53 2.939 6 9.788 3.166
Caffeine Yes 9 394.9 60.46 6 376.4 81.13
Hydroxyzine Yes 8 234.3 42.92 nd nd nd
Lucifer yellow No 15 3.37 0.328 6 1.734 0.0734
Methotrexate No 15 24.26 9.164 6 3.458 0.3547
Propanolol Yes 15 198.8 22.16 6 246.5 47.94
Risperidone Yes 11 143.1 22.54 6 184.5 29.01
Sulpiride No 15 26.41 5.003 6 10.29 1.157

Watson et al.

Watson et al. BMC Neuroscience 2013 14:59   doi:10.1186/1471-2202-14-59

Open Data