Email updates

Keep up to date with the latest news and content from BMC Neuroscience and BioMed Central.

Open Access Highly Accessed Research article

Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system

Maria GA Hägglund1, Sofie V Hellsten1, Sonchita Bagchi1, Anna Ljungdahl1, Victor CO Nilsson1, Sonja Winnergren1, Olga Stephansson1, Juris Rumaks2, Simons Svirskis2, Vija Klusa2, Helgi B Schiöth1 and Robert Fredriksson1*

Author Affiliations

1 Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden

2 Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia

For all author emails, please log on.

BMC Neuroscience 2013, 14:54  doi:10.1186/1471-2202-14-54

Published: 14 May 2013



The vesicular B0AT3 transporter (SLC6A17), one of the members of the SLC6 family, is a transporter for neutral amino acids and is exclusively expressed in brain. Here we provide a comprehensive expression profile of B0AT3 in mouse brain using in situ hybridization and immunohistochemistry.


We confirmed previous expression data from rat brain and used a novel custom made antibody to obtain detailed co-labelling with several cell type specific markers. B0AT3 was highly expressed in both inhibitory and excitatory neurons. The B0AT3 expression was highly overlapping with those of vesicular glutamate transporter 2 (VGLUT2) and vesicular glutamate transporter 1 (VGLUT1). We also show here that Slc6a17mRNA is up-regulated in animals subjected to short term food deprivation as well as animals treated with the serotonin reuptake inhibitor fluoxetine and the dopamine/noradrenaline reuptake inhibitor bupropion.


This suggests that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses.