Table 4

Regression formula for hypothesis 3A
Regression formula for the effect of Occluding filament type on Infarct size coefficient of variation (hypothesis 3A)
Variable (reference category) Variable categories Regression coefficient 0.95 confidence interval for regression coefficient p-value
Constant NA 49.1 38.7 59.4 0.000
Occluding filament type (Uncoated) Silicon coated −12.7 −18.3 −7.0 0.000
Poly-L-Lysine coated 3.1 −4.8 11.0 0.444
Other coatings 3.1 −5.0 11.3 0.451
Strain (Sprague Dawley) Wistar −2.1 −8.3 4.1 0.507
SHR −3.0 −17.2 11.2 0.679
WKY 16.1 −5.6 37.8 0.146
Other Strains 25.9 11.0 40.7 0.001
Sex (Male) Female 3.3 −17.0 23.7 0.747
Ovx female 12.1 −8.5 32.6 0.248
Mix or not specified −5.0 −15.1 5.2 0.335
Elderly rats [Yes] −17.8 −38.4 2.9 0.091
Type of anesthetic (inhalation anesthetic) Chloral Hydrate −12.0 −18.7 −5.4 0.000
Ketamine 4.5 −4.3 13.2 0.315
Barbiturates and bensodiazepines −12.4 −24.8 0.00 0.050
Other anesthetic −14.2 −24.1 −4.4 0.005
Awakening of rats during occlusion (No) [Yes] 10.4 2.1 18.6 0.014
Temperature feedback system (No) [Yes] −7.6 −14.1 −1.2 0.021
Blood pressure monitored (No) [Yes] −12.0 −21.4 −2.6 0.013
Heart rate monitored (No) [Yes] 14.9 5.4 24.4 0.002
Blood gases/O2saturation analyzed (No) [Yes] 11.5 1.8 21.1 0.021
Blood hemoglobin concentration analyzed (No) [Yes] 10.7 1.5 19.9 0.023
Occlusion duration (Short transient) Long transient −3.3 −9.3 2.8 0.288
Permanent −21.4 −30.1 −12.8 0.000
Time after focal ischemia for evaluation of damage [Continuous; Hours] 0.000036 −0.000013 0.000087 0.157
Blinding of infarct size determination procedure (No) [Yes] −3.8 −9.9 2.2 0.211
Criteria for excluding rats (None) Observed absence of cerebral blood flow reduction −7.4 −13.1 −1.7 0.011
Lack of functional deficit −5.6 −12.0 0.7 0.083
Too small infarct 7.6 −4.5 19.6 0.219
Other pathology in animal 16.2 8.7 23.6 0.000

Variables excluded by statistical software due to too low explanatory value: Weight, Intubation, Postoperative antibiotics, Blood glucose concentration analyzed, Type of infarct size evaluation, Edema correction used.

Ström et al.

Ström et al. BMC Neuroscience 2013 14:41   doi:10.1186/1471-2202-14-41

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