PPI network showing how ANG and its neighbours are linked to genes causing ALS. ANG (blue node) is connected to ALS associated proteins (red nodes) via intermediate proteins identified by expanding the network to include higher neighbourhood levels using NeuroDNet. Proteins that are up-regulated (green circles) or down-regulated (yellow circles) by ANG in HUVECs appear as the third neighbour of ANG.
Vasaikar et al. BMC Neuroscience 2013 14:3 doi:10.1186/1471-2202-14-3