NF-κB, cytokines and iNOS profile in different experimental groups. A & B) Change in NF-κB activity and protein levels were detected in induced versus resveratrol administered groups. We show that AlCl3 administration induced significantly (*p < 0.01) NF-κB activity with more p65 dissociation from the p105 complex as represented in the western blot. On the contrary co-administration of resveratrol with AlCl3 in both pre- and con- groups significantly decreased (**p < 0.05) NF-κB activity as well as p105 complex dissociation (B). Resveratrol inhibits AlCl3-induced TNF-α, IL-6 cytokine and iNOS expression in rat brain (C).
Zaky et al. BMC Neuroscience 2013 14:26 doi:10.1186/1471-2202-14-26