The effect of various concentrations of glucose on the activation of ERK, JNK and p38 MAPKs in NSCs following in vitro ischemia. Significant changes in the levels of phosphorylated ERK, JNK and p38 were observed in NSCs exposed to different concentrations of glucose following in vitro ischemia. (a) The p-ERK2 level was decreased in NSCs treated with 41.75 and 83.75 mM glucose after 6 h ischemic exposure, but no significant change in the p-ERK2 level was observed between the normal glucose group (17.5 mM) and the 27.75 mM glucose group. (b-c) Both p-p38 and p-JNK significantly increased in NSCs of the three glucose treatment groups (27.75, 41.75, and 83.75 mM) compared with the normal glucose group cells. *P < 0.05 versus control, analyzed by one-way ANOVA/Bonferroni post hoc test.
Chen et al. BMC Neuroscience 2013 14:24 doi:10.1186/1471-2202-14-24