Functional characterization of the DIV capillary-venule system. Hyperosmolar opening of the BBB in DIV models was assessed by real time measurements of TEER. Similar to what observed in vivo the differential magnitude and the transient nature of the vascular opening is indicative of the formation of capillary and venule vascular beds that closely mimic the physiological response of the corresponding cerebrovascular segments in situ.
Cucullo et al. BMC Neuroscience 2013 14:18 doi:10.1186/1471-2202-14-18