IGFBP-2 protein levels following hypoxic-lschemic injury. IGFBP-2 levels of sham animals are not significantly different between the left and the right hemispheres for the brain regions analyzed (A, C). For the brain regions analyzed, IGFBP-2 levels are not significantly different between the contralateral and stroke hemispheres 24 h post-stroke (B). IGFBP-2 levels on the stroke hemisphere increase significantly (*) in the penumbra (5-fold) and core (3-fold) when compared to the contralateral hemisphere 72 h post-stroke (D). For statistical analysis, for each brain region, IGFBP-2 levels of the two hemispheres were compared. (*) on the graphs denotes the brain regions where the statistical analysis revealed a significant difference between the stroke and the contralateral hemisphere. Results are mean ± S.D. n = 5; *p < 0.05 by ANOVA contralateral hemisphere vs. stroke hemisphere.
Fletcher et al. BMC Neuroscience 2013 14:158 doi:10.1186/1471-2202-14-158