itpr levels in peptidergic neurons are critical for the starvation resistance phenotype. (A) Flies with knock down of itpr using pan-neuronal and dimm drivers show starvation resistance as compared to the wild type whereas itpr knock down in either Dilp2 neurons or fat bodies do not show any starvation resistance. (B) Flies with knock down of itpr in Dilp2 neurons and dimm neurons using UASitpr-GFP showed decrease in GFP levels when compared to their controls without knockdown, cell bodies shown by arrow heads. Scale bar is 50 μm. (C) Over-expression of itpr+ in both pan-neuronal and peptidergic domains rescues starvation resistance observed in itprku.
Subramanian et al. BMC Neuroscience 2013 14:157 doi:10.1186/1471-2202-14-157