Additional file 8: Figure S8.
Synergistic phosphorylation of P90RSK upon combinatorial NGF (0-50 ng/ml) and PACAP (0-100 ng/ml) treatments. (a) Fold changes of pP90RSK under (i) uni-ligand treatments, (ii) bi-ligand treatments at 10 ng/ml of NGF, and (iii) bi-ligand treatments at 50 ng/ml NGF. (b) Representative images of cells treated with growth factors (50 ng/ml)-PACAP (100 ng/ml) in the presence of BRD7389 in the three systems. Significant differences between combinatorial experimental treatment of NGF-PACAP and summation of their individual effects were calculated using the paired Student’s t-test. A value of p<0.05 was considered significant (**p<0.01).
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Seow et al. BMC Neuroscience 2013 14:153 doi:10.1186/1471-2202-14-153