Table 2

NIH DAVID functional annotation clustering of autism-associated genes found to be significantly altered in postpartum LS
Cluster Enrichment score Genes
Synapse/Cell Junction 7.69 Cadps Ctnnb1 Gabrd Pclo Syt6
Rasgrp2 Cplx2 Grik1 Scn1a
Snapin Cpeb1 Grm3 Sv2c
Adora2a Dlg1 Lrfn1 Synpr
Camk2a Gabra4 Phactr1 Syt5
Regulation of synaptic plasticity/transmission 4 Hras1 Drd1a
Adora2a Grik1
Camk2a Grm3
Cpeb1
Drd2
Neuron projection morphogenesis 3.75 Dscam Adora2a Gas7
Klf7 Baiap2 Nr2e1
Sh2b1 Ctnnb1 Phgdh
Slitrk1 Cxcr4 Actg1
Alcam Drd2 Robo2
Cyclic nucleotide mediated signaling 3.35 Htr5a Pclo
Adora2a Tshr
Drd2
Drd1a
Gna11
Cell morphogenesis/differentiation 2.73 Dscam Cxcr4
Klf7 Drd2
Slitrk1 Nr2e1
Alcam Robo2
Ctnnb1
Neurogenesis/nervous system development 2.48 Ascl1 Smo
Ctnnb1 Robo2
Drd2 Socs2
Mapt
Nr2e1
Regulation of glutamine/amine/GABA signaling 2.44 Adora2a
Drd2
Drd1a
Grik1
Nnat
Cell motility/migration 2.4 Flt1 Drd1a
Ascl1 Nr2e1
Cxcr4 Pex5l
Cx3cl1 Smo
Drd2

Enrichment scores were calculated for all 160 autism-associated genes found in significant postpartum LS results (FDR-adjusted p < 0.25, Additional file 2: Table 2) by NIH DAVID’s functional annotation clustering with “high” stringency setting selected.

Eisinger et al.

Eisinger et al. BMC Neuroscience 2013 14:147   doi:10.1186/1471-2202-14-147

Open Data