Open Access Highly Accessed Research article

Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice

Pawel Lisowski1*, Grzegorz R Juszczak2, Joanna Goscik3, Adrian M Stankiewicz2, Marek Wieczorek4, Lech Zwierzchowski1 and Artur H Swiergiel56

Author Affiliations

1 Department of Molecular Biology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postepu 36A, 05-552, Magdalenka, Jastrzebiec n/Warsaw, Poland

2 Department of Animal Behavior, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postepu 36A, Jastrzebiec n/Warsaw, Poland

3 Department of Software Engineering, Bialystok Technical University, Wiejska 45A, Bialystok, Poland

4 Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Lodz, Poland

5 Department of Animal and Human Physiology, Institute of Biology, Gdansk University, Wita Stwosza 59, Gdansk, Poland

6 Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, USA

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BMC Neuroscience 2013, 14:144  doi:10.1186/1471-2202-14-144

Published: 13 November 2013

Additional files

Additional file 1: Table S1:

Primers. List of primers for investigated genes.

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Additional file 2: Table S2:

HA_SAL_HP_vs_HA_DES_HP. Lists of probe set for genes with altered expression after chronic desipramine treatment in the hippocampus of HA mice.

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Additional file 3: Table S3:

LA_SAL_HP_vs_LA_DES_HP. Lists of probe set for genes with altered expression after chronic desipramine treatment in the hippocampus of LA mice.

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Additional file 4: Table S4:

HA_GO_FAT. Gene Ontology categories of differentially expressed genes in the hippocampus of saline-treated HA mice vs. desipramine-treated HA mice. Significantly enriched (p < 0.05) gene ontology (GO) categories of differentially expressed genes (DEGs) in the hippocampus of saline-treated HA mice vs. desipramine-treated HA mice. GO categories shown in the figure consist of biological processes, molecular functions, cellular components and biochemical pathways terms.

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Additional file 5: Table S5:

LA_GO_FAT. Gene Ontology categories of differentially expressed genes in the hippocampus of saline-treated LA mice vs. desipramine-treated LA mice. Significantly enriched (p < 0.05) gene ontology (GO) categories of differentially expressed genes (DEGs) in the hippocampus of saline-treated LA mice vs. desipramine-treated LA mice. GO categories shown in the figure consist of biological processes, molecular functions, cellular components and biochemical pathways terms.

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