|Parameters and target functions of the flux balance analyses|
|Experiment||Performed FBA with the||Flux range|
|corresponding target function||[μM·h−1]|
|Normal nerve cell||minApo, maxApo, minDeg, maxDeg||-|
|Drug influence (MPTP)||minApo, maxDeg||0-100|
|Increased αSYN flux||minApo, maxDeg||0-100|
|Increased tyrosine flux||minApo, maxDeg||0-100|
Six experiments were performed. For each experiment, at least two different FBAs were performed with different target functions and variable flux ranges that are denoted in the last table column. Abbreviations: minimizing the output-reaction of the apoptosis (minApo), maximizing the output-reaction of the apoptosis (maxApo), minimizing the output-reaction of the degradation (minDeg), maximizing the output-reaction of the degradation (maxDeg), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Büchel et al.
Büchel et al. BMC Neuroscience 2013 14:136 doi:10.1186/1471-2202-14-136