IGFBP-4 protein expression in postnatal rat brains. (A) The temporal expression of IGFBP-4 protein in specific brain regions. (For the cerebral cortex, *- The level of IGFBP-4 protein at P70 was significantly lower than at other time-points in the cerebral cortex. For the cerebellum, *- The level of IGFBP-4 protein in the cerebellum at P0 was significantly lower than at P21, P28, and P70; ▲- - The level of IGFBP-4 protein at P7 was significantly lower than that at P28 in the cerebellum. For the midbrain, there is not significant difference between different time-points. All P < 0.05) (B) The spatial expression of IGFBP-4 protein at specific time points. (At P0, there is not significant difference between different brain regions. At P7, *- the level of IGFBP-4 protein was lower in the midbrain than in the cerebral cortex and cerebellum. At P14, P21, and P28, ★- the IGFBP-4 protein in the cerebellum was higher than in the cerebral cortex and midbrain. At P70, *- the IGFBP-4 protein in the cerebral cortex was lower than in the cerebellum and midbrain; ▲- in midbrain is lower than in the cerebellum; ★- in the cerebellum was highest. All P < 0.05).
Jiang et al. BMC Neuroscience 2013 14:132 doi:10.1186/1471-2202-14-132