Table 5

Cell-type marker enrichment of coexpression modules in each network
Control Network
Low stringency threshold ( > 4-fold)
Module Theme Module No. Oligodendrocyte Neuron Astrocyte
Oxidative phosphorylation CTL24 43 253*** 48
Glutamine metabolism CTL20 23* 9 166***
Myelination CTL25 115*** 16 42
Immune-related CTL1 7 10 44***
Synaptic transmission CTL18 7 85*** 9
Schizophrenia Network
Low stringency threshold ( > 4-fold)
Module Theme Module No. Oligodendrocyte Neuron Astrocyte
Oxidative phosphorylation SZ3 23 181*** 22
Glutamine metabolism SZ9 41*** 20 203***
Myelination SZ20 109*** 16 28
Immune-related SZ15 3 4 11
Ubiquitination SZ2 34 157*** 36

For the top disease-associated clusters in each network we report the number of genes that overlap with published lists of cell-type marker genes for oligodendrocytes , neurons, and astrocyte marker genes provided by [15]. Cell-type enrichment for all modules in each network and results for high stringency lists (> 10-fold) can be found in Additional file 4: Table 1. Hypergeometric probabilities were computed to evaluate significance of overlap. *pā€‰<ā€‰0.05; ***pā€‰<ā€‰< 0.001.

Mistry et al.

Mistry et al. BMC Neuroscience 2013 14:105   doi:10.1186/1471-2202-14-105

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