Table 1

Monoamines and their metabolites in the cortex and striatum of mGlu2/3−/− double knockout and wild-type (WT) mice
Cortex Striatum
mGlu2/3 WT mGlu2/3−/− mGlu2/3 WT mGlu2/3−/−
Dopamine 1.7 +/− 0.51 1.4 +/− 0.34 49.8 +/−3.38 37.8 +/− 2.40a
DOPAC 0.6 +/− 0.13 0.5 +/− 0.09 3.8 +/− 0.23 2.7 +/− 0.22b
HVA 0.8 +/− 0.10 0.9 +/− 0.12 4.9 +/− 0.33 3.9 +/− 0.28c
Noradrenaline 1.6 +/− 0.08 1.8 +/− 0.07 1.4 +/− 0.07 1.6 +/− 0.15
MHPG 2.2 +/− 0.17 2.9 +/− 0.14d 4.3 +/− 0.38 4.2 +/− 0.41
5HT 2.9 +/− 0.13 3.1 +/− 0.09 3.5 +/− 0.20 3.6 +/− 0.23
5HIAA 1.1 +/− 0.08 1.3 +/− 0.08 1.8 +/− 0.11 1.8 +/− 0.12

n=12-16 mGlu2/3−/− mice, and 12–14 WT mice. Values are pmol/mg tissue, mean ± SEM.

aF1,26 = 9.25, p=0.005.

bF1,26 = 9.85, p=0.004.

cF1,26 = 5.84, p=0.023.

dF1,24 = 11.1, p=0.003.

Lane et al.

Lane et al. BMC Neuroscience 2013 14:102   doi:10.1186/1471-2202-14-102

Open Data