Dopamine is reduced in tissue punches of the NAc but not dorsolateral striatum of mGlu2/3-/- mice. A: Dopamine content is reduced in tissue punches of NAc but not dorsolateral striatum of mGlu2/3-/- mice (black) compared to wildtypes (white). NAc n = 12 WT, 12 KO and dorsolateral striatum n=12 WT, 14 KO. B: DOPAC shows a trend towards reduction in the NAc of mGlu2/3-/- mice (p=0.1). NAc n = 12 WT, 14 KO and dorsolateral striatum n= 12 WT, 15 KO. Monoamine concentration is normalised to the total protein content of the punches. Graphs show mean ±SEM; all one-way ANOVA except striatal DOPAC, analysed with Mann Whitney U test, *p=0.037.
Lane et al. BMC Neuroscience 2013 14:102 doi:10.1186/1471-2202-14-102