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This article is part of the supplement: Twenty First Annual Computational Neuroscience Meeting: CNS*2012

Open Access Poster presentation

NeRvolver: a computational intelligence-based system for automated construction, tuning, and analysis of neuronal models

Emlyne Forren, Myles Johnson-Gray, Parth Patel and Tomasz G Smolinski*

Author Affiliations

Department of Computer and Information Sciences, Delaware State University, Dover, DE 19901, USA

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BMC Neuroscience 2012, 13(Suppl 1):P36  doi:10.1186/1471-2202-13-S1-P36

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/13/S1/P36


Published:16 July 2012

© 2012 Forren et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Poster presentation

Building neuronal models, even on the single-cell level, requires tremendous amounts of effort invested in the design of a realistic and functioning structure (e.g., the number and characteristics of compartments) and proper tuning of the model’s parameter values (e.g., membrane and axial conductances). Due to the ever-increasing computational power of modern computers facilitating the use of more and more complex neuronal models, hand-tuning of models’ parameters is becoming less and less feasible. Therefore, automated methods for neuronal model construction have been lately gaining much attention. Although a significant number of techniques for automatic model parameter estimation have been recently proposed (e.g., [1,3,4]), they are predominantly limited to “fine-tuning” of already designed models in a predetermined search space of parameter values. Furthermore, although unquestionably successful, present approaches are almost exclusively domain-specific, designed to deal with particular neuron types, or explicit classes of electrical activity (e.g., spiking neurons). Finally, most of the existing systems attempt to produce a single, best-matching model, and rely on a direct comparison between the voltage trace of the model and its biological equivalent.

Here, we propose a computational intelligence-based system for automated construction and tuning of neuronal models that builds upon the existing research in the area of automatic neuron model parameter optimization, but at the same time significantly expands the current approaches. The system, called NeRvolver, is designed to not only optimize the parameters of existing neuronal models, but also to allow for creation of entire sets of models matching some predefined criteria (e.g., in terms of the neuron’s characteristics such as spike height, inter-spiking interval, burst duration, period, etc.) “from scratch” (by utilizing, for example, only a limited set of generic currents as the starting point in the process of model construction). Furthermore, in addition to generating neuronal models, through the hybridization of multi-objective evolutionary algorithms (MOEA) and fuzzy logic (FL), the system generates classification rules describing biological phenomena discovered during the process of model creation or tuning (e.g., “IF sodium axon conductance is low, THEN spike frequency is low”). The purpose of generating such rules is twofold: 1) they can be used in subsequent runs of the modeling algorithm to improve its convergence time, and 2) they may potentially provide insights into the functioning of the biological neurons being modeled. For example, by using the aforementioned rule, the system may automatically increase the sodium axon conductance across the individuals in the evolutionary algorithm’s current population, if a higher spike frequency is desired. This is akin to the idea of local improvement of the genetic material using memes in memetic algorithms [2]. In addition, based on the above-quoted rule, the conclusion may be drawn that sufficient sodium axon conductance is necessary for adequate spike frequency. Such inferences, here automatically generated by the modeling system, can obviously be extremely useful for the understanding of the underlying biological phenomena.

Acknowledgements

Support: NSF HBCU-UP 0928404 to EF, NIH NIGMS HBCU-RISE R25GM089669 to MJG, NIH NCRR 5P20RR016472-12 and NIGMS 8P20GM103446-12 to PP, NSF EPSCoR 0814251 to TGS.

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