Open Access Highly Accessed Research article

Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis

Ramon Guirado12, David Sanchez-Matarredona1, Emilo Varea12, Carlos Crespo12, José Miguel Blasco-Ibáñez12 and Juan Nacher12*

Author Affiliations

1 Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt., Universitat de València, Spain

2 INCLIVA: Fundación Hospital Clínico Universitario de Valencia, València, Spain

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BMC Neuroscience 2012, 13:5  doi:10.1186/1471-2202-13-5

Published: 5 January 2012

Additional files

Additional file 1:

Quantification of PSA-NCAM and SYN expressing puncta in the hippocampus. Confocal image showing the expression of PSA-NCAM and SYN in the hippocampus. Focal planes showing the original image and the processed image for the puncta analysis for (B1 and B2) PSA-NCAM, (C1 and C2) SYN and (D1 and D2) the composite image. Scale bar: 320 μm in A and 5 μm in the rest.

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Additional file 2:

Statistical values of puncta expressing different markers. Statistical information of the expression of the different markers and its colocalization in the diferent regions of the mPFC, the hippocampus and the amygdala.

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Additional file 3:

Graphs for the dot size and surface covered by puncta expressing different markers in the Mpfc. Graphs representing the dot size and surface covered by puncta expressing different markers in the prelimbic and cingulate cortex of the medial prefrontal cortex. White bars represent control animals and black bars represent fluoxetine treated animals respectively.

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Additional file 4:

Graphs for the dot size and surface covered by puncta expressing different markers in the amygdala. Graphs representing the dot size and surface covered by puncta expressing different markers in different areas of the amygdala. White bars represent control animals and black bars represent fluoxetine treated animals respectively.

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Additional file 5:

Graphs for the dot size and surface covered by puncta expressing different markers in the hippocampus. Graphs representing the dot size and surface covered by puncta expressing different markers in different areas of the hippocampus. White bars represent control animals and black bars represent fluoxetine treated animals respectively.

Format: JPEG Size: 678KB Download file

Open Data