Electroretinogram analysis in APPswe/PS1 bigenic mice. Dark-adapted ERG amplitudes were measured in control and groups received 3-month (light-3 m) and 6-month (light-6 m) CILEs as described in the Methods. (A) The rod-isolated ERG response stimulated by a flash at 0.008 cd/m2 s (-25 dB). (B) The maximal ERG response by a flash at 2.5 cd/m2s (0 dB). T indicates start of the test; N, the baseline of the recording when light stimulation was given. Quantifications include measures from 12 mice for each group, i.e., N = 12. *: P < 0.001, Bars depict mean ± SEM.
Dong et al. BMC Neuroscience 2012 13:34 doi:10.1186/1471-2202-13-34