Table 7

HPLC analysis results of 5-HT,5-HIAA and 5-HIAA/5-HT in the hippocampus and hypothalamus of foetuses

Groups

n

Position

5-HT (ng/g)

5-HIAA (ng/g)

5-HIAA/5-HT


Female foetuses of control

47

Hippocampus

215.4 ± 15.8

165.1 ± 9.6

0.771 ± 0.041


(210.8~220.0)

(162.3~167.9)

(0.759~0.783)


Hypothalamus

116.9 ± 8.2

44.5 ± 5.5

0.382 ± 0.021


(114.5~119.3)

(42.9~46.1)

(0.376~0.388)


Female foetuses of CUS

43

Hippocampus

236.3 ± 16.1**

135.8 ± 15.7**

0.572 ± 0.059**


(231.3~241.3)

(130.9~140.7)

(0.554~0.590)


Hypothalamus

146.7 ± 13.8**

46.1 ± 3.3

0.313 ± 0.052**


(142.5~150.9)

(45.1~47.2)

(0.297~0.329)


Male foetuses of control

40

Hippocampus

206.7 ± 16.4

173.2 ± 12.8

0.84 ± 0.069


(201.4~212.0)

(169.1~177.3)

(0.818~0.862)


Hypothalamus

141.6 ± 15.2

54.9 ± 3.8

0.391 ± 0.044


(136.7~146.5)

(53.7~56.1)

(0.377~0.405)


Male foetuses of CUS

49

Hippocampus

238.5 ± 10.5**

149.3 ± 10.2**

0.633 ± 0.07**


(235.5~241.5)

(146.4~152.2)

(0.613~0.653)


Hypothalamus

175.3 ± 13.3**

53.2 ± 6.3

0.312 ± 0.042**


(171.5~179.1)

(51.4~55.0)

(0.300~0.324)


Data are mean ± S.D. Data in bracket are 95% confidence intervals for each relevant statistic. **: P < 0.01 compared with control by the same sex and the same position

Huang et al. BMC Neuroscience 2012 13:22   doi:10.1186/1471-2202-13-22

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