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Open Access Highly Accessed Research article

Minocycline reduces reactive gliosis in the rat model of hydrocephalus

Hao Xu13, Guowei Tan12, Shaolin Zhang13, Hongwei Zhu1, Feng Liu1, Caiquan Huang1, Feifei Zhang1 and Zhanxiang Wang1*

Author affiliations

1 Department of Neurosurgery, First Affiliate Hospital of Xiamen University, Xiamen, Fujian Province, 361003, China

2 School of Life Science, Xiamen University, Xiamen, Fujian Province, 361003, China

3 Medical College of Xiamen University, Xiamen, Fujian Province, 361003, China

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Citation and License

BMC Neuroscience 2012, 13:148  doi:10.1186/1471-2202-13-148

Published: 5 December 2012

Abstract

Background

Reactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, to reduce reactive gliosis and inhibit the development of hydrocephalus.

Results

The ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP and Iba-1were detected by RT-PCR, Immunohistochemistry and Western blot. The expression of GFAP and Iba-1 was significantly higher in hydrocephalic group compared with saline control group (p < 0.05). Minocycline treatment of hydrocephalic animals reduced the expression of GFAP and Iba-1 significantly (p < 0.05). Likewise, the severity of ventricular dilatation is lower in minocycline treated hydrocephalic animals compared with the no minocycline group (p < 0.05).

Conclusion

Minocycline treatment is effective in reducing the gliosis and delaying the development of hydrocephalus with prospective to be the auxiliary therapeutic method of hydrocephalus.

Keywords:
Hydrocephalus; Gliosis; Astrocytosis; Microgliosis; Minocycline