Resolution:
## Figure 1.
Multiple connections between CA3 and CA1 pyramidal cells and GABAergic cells and CA1
pyramidal cells in young adult rats. (A_{1}) A typical recording at -80 mV from a pyramidal cell, upper trace shows AMPA sEPSCs
under control conditions and lower trace shows mEPSCs after wash-in of TTX. (A_{2}) TTX reduces the AMPA EPSC amplitude by 5.9 ± 0.8 pA (P = 0.004, n = 8, two-tailed
paired t-test). (A_{3}) TTX reduces AMPA EPSC frequency by 1.5 ± 0.4 Hz (P < 0.001, n = 8, one-tailed paired
t-test). (A_{4}) The average multiplicity was 1.7 ± 0.1 (P < 0.001, n = 8, one-tailed one-sample
t-test with test value = 1). (B_{1}) A typical recording at 0 mV from a pyramidal cell, upper trace shows GABA sIPSCs
under control conditions and lower trace shows mIPSCs after wash-in of TTX. (B_{2}) TTX reduces the GABA IPSC amplitude by 8.4 ± 2.7 pA (P = 0.03, n = 6, two-tailed
paired t-test). (B_{3}) TTX reduces GABA IPSC frequency by 3.2 ± 0.8 Hz (P = 0.005, n = 6, one-tailed paired
t-test). (B_{4}) The average multiplicity was 2.4 ± 0.4 (P = 0.007, n = 6, one-tailed one-sample
t-test with test value = 1). Black filled circles show mean ± SEM and green filled
circles show data from individual experiments. Asterisks denote the level of significance
as follows: *: P < 0.05, **: P < 0.01, ***: P < 0.001.
Riebe and Hanse |