Table 1

Differentiation-induced changes in membrane properties of NG108-15 cells
RMP Vmax Depolarization amplitude Current threshold
n (mv) (mV/ms) (mV) (pA)
Day 0 22 −34.9 ± 1.4 20.1 ± 0.9 32.1 ± 1.6 n/a
Day 9 15 −43.2 ± 1.5* 23.2 ± 1.2 45.0 ± 2.9* n/a
Day 21
Without AP 30 −45.4 ± 2.1* 28.5 ± 3.5* 46.1 ± 4.7* n/a
Day 21
with AP 25 −56.1 ± 1.6*#$ 136.1 ± 13.7*#$ 79.4 ± 7.4*#$ 48.2 ± 2.7

RMP resting membrane potential; Vmax maximum rate of depolarization of action potential (AP). Data are means ± SEM, n is the number of cells studied. *P < 0.05 vs. 0 day of differentiation (day 0, undifferentiated cells); #P < 0.05 vs. cells after 9 days of differentiation (day 9); $P < 0.05 vs. cells after 21 days of differentiation (day 21) without AP.

Liu et al.

Liu et al. BMC Neuroscience 2012 13:129   doi:10.1186/1471-2202-13-129

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