Hierarchical cluster analysis of ethanol-induced changes in expression of 40 genes involved in cell proliferation, DNA repair, and apoptosis genes seen in mouse NSCs (columns 1-4) and rat PBLs (columns 5-12). Note that very few differences were noted due to growth factor conditions in vitro (FGF, TGF) or to gender. Also note that most of the genes in the top of the cluster diagram are decreased in expression and involved in mitotic cell cycle regulation (e.g., cyclin B2, pituitary tumor-transforming gene 1). In contrast, genes involved in DNA repair and apoptosis tended to show increases in expression, although the changes varied by cell type.
Hicks et al. BMC Neuroscience 2012 13:128 doi:10.1186/1471-2202-13-128