Table 2

Neuronal death (apoptosis) and neuronal survival at 7 days post-SE in the rat hippocampus
Neurones Control Epilepsy Antagomir Antagomir-control
CA1 CA3 CA1 CA3 CA1 CA3 CA1 CA3
Percent Death 17.91 ± 4.78% 20.57 ± 5.02% 48.86 ± 12.39% a 40.39 ± 11.42% a 30.49 ± 8.91% b 24.80 ± 5.80% b 49.35 ± 12.74% 40.69 ± 10.97%
Percent Survival 88.15 ± 10.02% 78.89 ± 8.92% 47.32 ± 11.93% a 51.25 ± 14.80% a 72.81 ± 10.60% b 68.28 ± 11.54% b 46.26 ± 9.50% 52.05 ± 14.70%

Notes: In rat hippocampal CA1 and CA3 regions, the number of dead neurones or apoptotic cells was significantly increased and the number of surviving neurones was markedly decreased at 7 days post-SE, as detected by the TUNEL-assay and Nissl-staining (aP < 0.01, epilepsy vs control, n = 6 /group). In the same regions, however, neuronal death or apoptosis was decreased and neuronal survival was increased significantly after miR-34a antagomir or antagomir-control treatment (bP < 0.01, miR-34a antagomir vs antagomir-control, n = 6 /group). The survival rate is determined by the number of surviving neurones/ number of total cells × 100%, whereas the neuronal death or apoptotic rate is determined by the number of dead neurones or apoptotic cells/ number of total cells × 100%.

Hu et al.

Hu et al. BMC Neuroscience 2012 13:115   doi:10.1186/1471-2202-13-115

Open Data