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Open Access Highly Accessed Research article

Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons

Li Nan Zhang12, Su Wen Su1, Fang Guo1, Hui Cai Guo3, Xiao Lu Shi1, Wen Ya Li1, Xu Liu1 and Yong Li Wang1*

Author Affiliations

1 Department of Pharmacology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, China

2 Department of Pharmacy, College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 70 Yuhua East Road, Shijiazhuang, 050018, China

3 Department of Toxicology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, China

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BMC Neuroscience 2012, 13:10  doi:10.1186/1471-2202-13-10

Published: 19 January 2012

Abstract

Background

The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons.

Results

5-HT (0.1, 1 mM) showed Na+/K+ pump current (Ip) densities of 0.40 ± 0.04, 0.34 ± 0.03 pA/pF contrast to 0.63 ± 0.04 pA/pF of the control of 0.5 mM strophanthidin (Str), demonstrating 5-HT-induced inhibition of Ip in a dose-dependent manner in hippocampal CA1 pyramidal neurons. The effect was partly attenuated by ondasetron, a 5-HT3 receptor (5-HT3R) antagonist, not by WAY100635, a 5-HT1AR antagonist, while 1-(3-Chlorophenyl) biguanide hydrochloride (m-CPBG), a 5-HT3R specific agonist, mimicked the effect of 5-HT on Ip.

Conclusion

5-HT inhibits neuronal Na+/K+ pump activity via 5-HT3R in rat hippocampal CA1 pyramidal neurons. This discloses novel mechanisms for the function of 5-HT in learning and memory, which may be a useful target to benefit these patients with cognitive disorder.