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This article is part of the supplement: Twentieth Annual Computational Neuroscience Meeting: CNS*2011

Open Access Poster presentation

Inhibitory coverage of dendritic excitation

Albert Gidon1* and Idan Segev123

Author Affiliations

1 Department of Neurobiology, The Hebrew University of Jerusalem, Israel

2 Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel

3 Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Israel

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BMC Neuroscience 2011, 12(Suppl 1):P291  doi:10.1186/1471-2202-12-S1-P291

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/12/S1/P291


Published:18 July 2011

© 2011 Gidon and Segev; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Poster presentation

“The Coverage Problem” is a class of optimization problems used in different fields that aims to explore the best strategy in order to maximally “cover” a region under some constrains. For example, how could a limited number of cellular antennas be distributed such that their signals would cover a maximal region (e.g., a whole city) while limiting the radio-frequency radiation to safe levels? Here we ask whether the notion of coverage could be applied to inhibitory synapses, giving them optimal control over the excitatory/excitable activity in the dendritic tree. In support of this idea is the fact that most (85%) [1-3] inhibitory synapses target dendrites rather than operate at the soma/axon region as a global veto mechanism of the neuron’s output . Additionally, it seems to be the rule rather than the exception that single inhibitory axons target specific dendritic sub-regions where each axon makes multiple synapses [4-6], implying that the role of such inhibition is to cover a particular dendritic region. Using analytic solutions of the cable theory as well as detailed compartmental models, we searched for the spatial distribution of inhibition that maximally covers the modeled dendrite under different constraints (e.g., fixed number of contacts per axon and fixed total inhibitory conductance). We explored the conditions in which the inhibitory coverage would be most effective in controlling the neuronal output and compared our results to the actual distributions of inhibitory synapses in different dendrites. We showed that despite the small number of inhibitory synapses (relative to the excitatory synapses) in dendrites of most central neurons, when the synapses are strategically placed, they can effectively dampen the excitatory/excitability activity in dendrites both globally and in a domain-specific manner.

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