The DGC coordinates actin cytoskeleton remodeling. (A) Scheme showing a cell with the DGC and found Dys/Dg-interacting components. Autofluorescence image shows a regular ommatidia pattern (B) which is disrupted by Dg323 clone induction (C). (D) DgO86 mutant clones (marked by the absence of nuclear GFP) in a Drosophila pupal eye stained with anti-phalloidin (Actin) and the nuclear marker DAPI. Rectangles indicate wt (upper) and mutant (lower) areas. An enlarged view of wt (E) and mutant (F) zones (indicated with rectangles in D) with GFP, DAPI, Arm and Actin cell markers in different channels. Dg-/- cells (GFP negative) have disorganized nuclei, improper Arm and Actin localization and shorter rhabdomeres when compared to sister wt cells (GFP positive). Yellow bars in lower panel indicate normal rhabdomere length.
Marrone et al. BMC Neuroscience 2011 12:93 doi:10.1186/1471-2202-12-93