Open Access Highly Accessed Research article

Transcriptomic analysis of the zebrafish inner ear points to growth hormone mediated regeneration following acoustic trauma

Julie B Schuck1, Huifang Sun1, W Todd Penberthy12, Nigel GF Cooper3, Xiaohong Li3 and Michael E Smith1*

Author Affiliations

1 Department of Biology, Western Kentucky University, 1906 College Heights Blvd., Bowling Green, KY 42101, USA

2 Department of Molecular Biology and Microbiology, Burnett School of Biomedical Science, University of Central Florida College of Medicine, 4000 Central Florida Blvd., Orlando, FL 32816, USA

3 Department of Anatomical Sciences & Neurobiology University of Louisville, School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA

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BMC Neuroscience 2011, 12:88  doi:10.1186/1471-2202-12-88

Published: 2 September 2011

Additional files

Additional file 1:

Differential gene expression at two days post-trauma compared to controls. This file presents all significantly regulated (P < 0.05) genes in zebrafish ears two days following acoustic trauma compared to controls, sorted by fold change. Following IPA notation, upregulated and downregulated genes with > 1.4 fold changes are labeled in red and green, respectively.

Format: XLS Size: 1.3MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Differential gene expression at four days post-trauma compared to controls. This file presents all significantly regulated (P < 0.05) genes in zebrafish ears four days following acoustic trauma compared to controls, sorted by fold change. Following IPA notation, upregulated and downregulated genes with > 1.4 fold changes are labeled in red and green, respectively.

Format: XLS Size: 426KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Differential gene expression at four days post-trauma compared to day two. This file presents all significantly regulated (P < 0.05) genes in zebrafish ears four days following acoustic trauma compared to two days post-trauma, sorted by fold change. Following IPA notation, upregulated and downregulated genes with > 1.4 fold changes are labeled in red and green, respectively.

Format: XLS Size: 570KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Significantly regulated functions at two days post-trauma. This file displays the categories and functions of significantly regulated genes in zebrafish ears two days following acoustic trauma compared to controls. In addition, specific molecules being regulating in each functional annotation are provided.

Format: XLS Size: 166KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

Significantly regulated functions at four days post-trauma. This file displays the categories and functions of significantly regulated genes in zebrafish ears four days following acoustic trauma compared to controls. In addition, specific molecules being regulating in each functional annotation are provided.

Format: XLS Size: 137KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 6:

Significantly regulated functions at four days post-trauma compared to day two. This file displays the categories and functions of significantly regulated genes in zebrafish ears four days following acoustic trauma compared to day two. In addition, specific molecules being regulating in each functional annotation are provided.

Format: XLS Size: 138KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data