Estimation of facilitation/augmentation and depletion following homosynaptic conditioning using the paired-pulse ratio. A. Relationship between relative synaptic weight and relative PPR for different conditioning (indicated in the figure with different symbols) normalized with respect to control. Control synaptic weight and control PPR are set to 1. Dotted blue line indicates the expected relationship when there is a selective change of the first EPSP in the paired-pulse protocol (resting-Pves). Green horizontal line indicates the expected relationship when there are equal changes of the first and of the second EPSP (pool). Error bars for the tHeSD are within the symbol. B. Estimation of the contribution of "resting Pves" depression (blue arrow), facilitation/augmentation (grey arrow) and depletion (blue arrow) to the postburst depression 500 ms after a 3-impulse (50 Hz) burst. C. Same as B, but for the postburst depression 500 ms after a 10-impulse (50 Hz) burst. D. Same as B, but for the postburst depression 500 ms after a 3-impulse (50 Hz) burst when astrocyte signaling was compromised either by 50 mM BAPTA intracellularly, or 1 mM fluoroacetate extracellularly (Andersson and Hanse, 2010).
Andersson and Hanse BMC Neuroscience 2011 12:87 doi:10.1186/1471-2202-12-87