GSPE inhibits synaptically-mediated [Ca2+]i spikes induced by treatment with 0.1 mM [Mg2+]o. A: Reduction of [Mg2+]o to 0.1 mM induced [Ca2+]i spikes. B: Pretreatment with GSPE (6 μg/ml) inhibited 0.1 mM [Mg2+]o-induced [Ca2+]i spikes. C: The plot summarizes the inhibition of GSPE on 0.1 mM [Mg2+]o-induced response (control, n = 8; 6 μg/ml, n = 7). The frequency of [Ca2+]i spikes was calculated from data collected during a 5 min window before GSPE application for control, and during a 5 min window 5-10 min after application of the drug for GSPE-treated samples. Data are expressed as the mean ± SEM. *P < 0.05 relative to control (unpaired Student's t-test).
Ahn et al. BMC Neuroscience 2011 12:78 doi:10.1186/1471-2202-12-78