Table 1

Significantly populated KEGG signaling pathways created by genes differentially regulated between learners and swimmers

KEGG Category

Transcripts

Fold change

p-value


MAPK signaling

brain derived neurotrophic factor

1.4041

0.0063

growth arrest and DNA-damage-inducible 45 alpha

1.2334

0.0000

dual specificity phosphatase 1

1.6577

0.0005

RAS related protein 1b

1.2067

0.0306

activin A receptor, type IC

1.3618

0.0000

dual specificity phosphatase 14

1.1473

0.0035

serine/threonine kinase 4

1.1598

0.0316

dual specificity phosphatase 6

1.5402

0.0000

Focal adhesion

catenin (cadherin associated protein), beta 1

1.2247

0.0051

cyclin D1

1.4578

0.0019

integrin beta 5

1.1444

0.0365

3-phosphoinositide dependent protein kinase-1

1.1971

0.0211

protein phosphatase 1, catalytic subunit, beta isoform

1.3220

0.0193

RAS related protein 1b

1.2067

0.0306

Actin cytoskeleton

integrin beta 5

1.1444

0.0365

myosin, heavy polypeptide 9, non-muscle

1.3739

0.0061

protein phosphatase 1, catalytic subunit, beta isoform

1.3220

0.0193

NCK-associated protein 1

1.1491

0.0427

actin related protein 2/3 complex, subunit 5

Insulin signaling

3-phosphoinositide dependent protein kinase-1

1.1971

0.0211

protein phosphatase 1, catalytic subunit, beta isoform

1.3220

0.0193

insulin receptor substrate 2

1.3744

0.0229

protein phosphatase 1, regulatory (inhibitor) subunit 3C

1.2373

0.0329

Wnt signaling

catenin (cadherin associated protein), beta 1

1.2247

0.0051

cyclin D1

1.4578

0.0019

protein phosphatase 2, regulatory subunit B, gamma isoform

1.2332

0.0396

protein phosphatase 2, regulatory subunit B, beta isoform

1.2616

0.0191


The table indicates the most significantly populated KEGG pathways and the corresponding genes from the input dataset (significantly regulated in learners versus swimmers) that were clustered into the respective pathways.

Park et al. BMC Neuroscience 2011 12:63   doi:10.1186/1471-2202-12-63

Open Data