Homogeneous upregulation of cortical BDNF expression following learning in aged mice. (A), Representative heat maps showing the pattern of BDNF mRNA expression in the aged mouse brain following learning, swimming, or home cage conditions. (B), Densitometric analysis revealed that learning enhanced BDNF expression in the anterior cingulate cortex (AC), auditory cortex (Au), entorhinal cortex (Ent), motor cortex (M), somatosensory cortex (Ss), retrosplenial cortex (Rs), and visual cortex (Vis). Asterisk (*) indicates significance at p < 0.05 following one-way ANOVA with Tukey's post hoc. Abbreviations used in (A) are the same as those used in (B) and (C); see Materials and Methods for detailed description of cortical anatomical sampling. (C), Levels of BDNF mRNA are comparable across regions involved in the associational and sensorimotor aspects of water maze training.
Park et al. BMC Neuroscience 2011 12:63 doi:10.1186/1471-2202-12-63