Learning and swimming recruit distinct gene expression profiles. (A), Genetic heatmap plot showing the cortical genes regulated, compared to home cage sedentary animals, by learning or swimming protocols. Red represents upregulation, while green shows downregulation. (B), Venn diagram showing the specific transcripts expressed in the aged mouse cortex following learning and swimming protocols. Learning-induced transcripts represent a subset of genes expressed following learning and swimming. This suggests that cortical gene expression partitions learning-related genes within physical activation- and arousal-related genes. (C), Data plot of individual gene z ratios of the learning versus swimming protocol analysis. Z ratios indicating both directions of relative gene regulation were observed.
Park et al. BMC Neuroscience 2011 12:63 doi:10.1186/1471-2202-12-63