Table 1

A comparison of the number of myelinated axons and labeled DRG and motor neurons contributing to MCN

MCN

Number of

Number of labeled sensory

Number of labeled

% of motor neurons

myelinated axons

and motor neurons

motor neurons

to MCN

(n ± SD)

to MCN (n ± SD)

to MCN (n ± SD)


Intact

1259 ± 98

1857 ± 115

308 ± 41

16.6

PBS

1473 ± 135‡

515 ± 40‡

51 ± 13‡

9.9

Cerebrolysin

1282 ± 124

477 ± 35‡

46 ± 11‡

9.6

CNTF

782 ± 78‡†

601 ± 34‡†

103 ± 20‡†

17.1


A comparison of the mean number of myelinated axons, all labeled neurons (DRG and motor neurons) and motor neurons contributing to MCN in the intact rats and the MCN stumps after end-to-side anastomosis in PBS-, Cerebrolysin- and CNTF-treated rats as well as percentage of motor neurons. Although total number of myelinated axons in MCN stump of rats treated with CNTF is lower than in those treated with PBS or Cerebrolysin, note that the number and percentage of motor neurons (labeled by green and yellow fluorescence) contributing their axons to MCN stump is significantly higher in CNTF-treated rats.

‡ indicates statistical significance (P < 0.05) when comparing rats of experimental groups with intact rats; † indicates statistical significance (P < 0.05) when comparing rats with ALZET minipumps filled with CNTF and Cerebrolysin or PBS.

Dubový et al. BMC Neuroscience 2011 12:58   doi:10.1186/1471-2202-12-58

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