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Open Access Highly Accessed Research article

Reduced CSF turnover and decreased ventricular Aβ42 levels are related

Jean-Marie Serot1*, Johann Peltier2, Antony Fichten2, Nelly Ledeme3, Anne-Marie Bourgeois3, Pierre Jouanny1, Patrick Toussaint2, Daniel Legars2, Olivier Godefroy4 and Jean-Claude Mazière3

Author Affiliations

1 Department of Gerontology, CHU Amiens, France

2 Department of Neurosurgery, CHU Amiens, France

3 Department of Biochemistry, INSERM ERI-12, CHU Amiens, France

4 Department of Neurology, CHU Amiens, France

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BMC Neuroscience 2011, 12:42  doi:10.1186/1471-2202-12-42

Published: 13 May 2011

Abstract

Background

The appearance of Aβ42 peptide deposits is admitted to be a key event in the pathogenesis of Alzheimer's disease, although amyloid deposits also occur in aged non-demented subjects. Aβ42 is a degradation product of the amyloid protein precursor (APP). It can be catabolized by several enzymes, reabsorbed by capillaries or cleared into cerebrospinal fluid (CSF). The possible involvement of a decrease in CSF turnover in A4β2 deposit formation is up to now poorly known. We therefore investigated a possible relationship between a reduced CSF turnover and the CSF levels of the A4β2 peptide.

To this aim, CSF of 31 patients with decreased CSF turnover were studied. These patients presented chronic hydrocephalus communicating or obstructive, which required surgery (ventriculostomy or ventriculo-peritoneal shunt). Nine subjects had idiopathic normal pressure hydrocephalus (iNPH), and the other 22 chronic hydrocephalus from other origins (oCH).

The Aβ42 peptide concentration was measured by an ELISA test in 31 ventricular CSF samples and in 5 lumbar CSF samples from patients with communicating hydrocephalus.

Results

The 5 patients with lumbar CSF analysis had similar levels of lumbar and ventricular Aβ42. A significant reduction in Aβ42 ventricular levels was observed in 24 / 31 patients with hydrocephalus. The values were lower than 300 pg/ml in 5 out of 9 subjects with iNPH, and in 15 out of 22 subjects with oCH.

Conclusion

The decrease of CSF Aβ42 seems to occur independently of the surgical hydrocephalus aetiology. This suggests that a CSF reduced turnover may play an important role in the decrease of CSF Aβ42 concentration.