Additional File 1.

APP/Rab7 as a diagnostic marker for impaired vesicle trafficking in MDF motor neurons. Immunohistochemical staining for Amyloid-Precursor Protein (APP,A) using rabbit anti-APP, and for Rab7 (B) using goat-anti-Rab7, and co-localisation of both proteins (C) in spinal cord motor neurons of 60 d.p.n. MDF mice. Note the large endosomal vesicles (arrows in C) staining positive for APP and Rab7, indicating a transport impairment in these motor neurons, similar to the ones observed in wobbler.

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Palmisano et al. BMC Neuroscience 2011 12:24   doi:10.1186/1471-2202-12-24