APP and Rab7 colocalise in degenerating motor neurons. Representative immunohistochemical staining for Amyloid-Precursor Protein (APP) (A,D,G) using rabbit anti-APP, and for Rab7 (B,E,H) using goat-anti-Rab7, and co-localisation of both proteins (C,F,I) in spinal cord motor neurons of 42 d.p.n. wild-type (WT, A,B,C), age-matched wobbler (WR, D,E,F), and 120 d.p.n. SOD1G93A (G,H,I) transgenic mice. Note the spotty appearance of the large vesicular structures with up to 2.5 μm diameter in WR sections. These structures were not seen in WT and in SOD1 (G93A) transgenic spinal cord sections. Bar in A, valid for A-I, 5 μm.
Palmisano et al. BMC Neuroscience 2011 12:24 doi:10.1186/1471-2202-12-24