Table 3

[3H]-PK11195 binding parameters(a) in mouse membranes.

    Brain
:

Kd (nM)

Bmax (fmol/mg protein)


ob/ob Mutant

1.75 ± 0.3

403.5 ± 12.6 (*)


Wild Type

1.8 ± 0.2

329.5 ± 16.0


    Kidney
:

Kd (nM)

Bmax (fmol/mg protein)


ob/ob Mutant

1.9 ± 0.2

19550 ± 1180


Wild Type

2.0 ± 0.3

20260 ± 2017


(a): Data are presented as mean ± SD of n = 4 separate experiments in brain and kidney membrane preparations carried out in ob/ob and WT animals as indicated in the Methods sections. (*): Student t-test, p < 0.05.

Giannaccini et al. BMC Neuroscience 2011 12:18   doi:10.1186/1471-2202-12-18

Open Data