Table 2

[3H]-paroxetine binding parameters(a) in mouse membranes.

    Brain:

Kd (nM)

Bmax (fmol/mg protein)


ob/ob Mutant

0.1 ± 0.01

368 ± 17.5


Wild Type

0.09 ± 0.01

341 ± 18.0


    Platelets
:

Kd (nM)

Bmax (fmol/mg protein)


ob/ob Mutant

0.09 ± 0.008

18680 ± 2278


Wild Type

0.08 ± 0.01

14830 ± 1722


(a): Data are presented as mean ± SD of n = 4 separate experiments in brain or platelet membrane preparations carried out in ob/ob and WT animals as indicated in the Methods section.

Giannaccini et al. BMC Neuroscience 2011 12:18   doi:10.1186/1471-2202-12-18

Open Data