Marcella Reale*, Antonia Patruno, Maria A De Lutiis, Mirko Pesce, Mario Felaco, Massimo Di Giannantonio, Marta Di Nicola and Alfredo Grilli
Corresponding author: Marcella Reale firstname.lastname@example.org
BMC Neuroscience 2011, 12:13 doi:10.1186/1471-2202-12-13
(2011-05-31 14:29) University of Cambridge
I was fascinated to read your study that seems to show a very robust difference in
levels of cytokines in unmedicated first episode patients with schizophrenia. I have
2 queries, relating to the subjects tested, and the measures of inflammation. Firstly, can you clarify for me the nature of the patients that you studied and how
the patients were recruited and from what setting? What was the length of untreated
illness in the patients and were they never medicated, or just unmedicated at the
time of testing? Only 10 of the 51 patients were subsequently treated with antipsychotics,
which would suggest to me that they were not acutely unwell. They do not seem like
a typical cohort of first episode psychosis patients in my experience. The diagnosis
at first presentation of psychosis is unreliable, with a later diagnosis of schizophrenia
in only a proportion of cases. I would therefore be interested in any further details
of the patients, to support the diagnoses given. Secondly, CRP and ESR were measured for all subjects, but the results are not given.
I wonder if they were also raised, in keeping with the other cytokines measured. Could
the authors comment on these. Thank you.
no competing interests
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