Basal AMPA receptor-mediated synaptic transmission is not altered by Kal7 deletion. A) Example traces of evoked field EPSPs (fEPSPs) in WT and Kal7KO mice. B) Input-output curve showing the relationship between stimulation intensity and presynaptic fiber volley for evoked AMPA receptor-mediated hippocampal fEPSPs. This is a measure of the excitability of the presynaptic axons that are being stimulated (WT: n = 8 slices from 3 animals; Kal7KO: n = 6 slices from 3 animals). C) Input-output curve showing relationship between presynaptic fiber volley and fEPSP amplitude for the same slices as in B. D) Input-output curve showing relationship between presynaptic fiber volley and fEPSP slope for the same slices as in B. There was no significant difference between WT and Kal7KO for either amplitude or slope.
Lemtiri-Chlieh et al. BMC Neuroscience 2011 12:126 doi:10.1186/1471-2202-12-126