Aging induces alterations in protein expression patterns of Caspase-1, pannexin-1 and P2X7R in hippocampal neurons. Confocal images show hippocampal neurons in the CA3 region of young and aged animals. Sections were stained for caspase-1, pannexin-1 and P2X7 (red) and the neuronal marker NeuN (green). In aged animals, the immunoreactivity of caspase-1, P2X7 and pannexin-1 are increased in neurons of the hippocampus compared to young animals with P2X7 and pannexin-1 showing a polarized distribution near the somatic membrane (arrows). Bar=20 μm.
Mawhinney et al. BMC Neuroscience 2011 12:123 doi:10.1186/1471-2202-12-123