Table 1

Candidates genes for FTO-interaction studies based on results from queries in Funcoup, Coxpresdb and IntAct (see Figure 1).

Candidate genes

Name

Function


PFN2

Profilin 2

Regulates actin polymerization in response to extracellular signals


NRTK2

Neurotrophic tyrosine kinase receptor type 2

Receptor for BDNF


BDNF

Brain derived neurotrophic factor

involved in neuronal plasticity & differentiation


PRKACB

cAMP dependent protein kinase catalytic subunit beta

Ser/Thr protein kinase, catalytic subunit of AMP-activated protein kinase (AMPK)


VAMP2

Vesicle-associated membrane protein 2. alt. Synaptobrevin-2

Involved in the targeting and/or fusion of transport vesicles to their target membrane.


STAT3

Signal transducer and activator of transcription 3

Transcription factor involved in cell growth and apoptosis. Responds to leptin signalling.


NLN

Neurolysin

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A


BTBD12

SLX4 structure-specific endonuclease subunit homolog

DNA-repair, endonuclease activity.


ZBTB20

Zinc finger and BTB domain-containing protein 20

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses


ATF7IP

Activating transcription factor 7-interacting protein

A regulator of telomerase reverse transcriptase (TERT) expression


STAT3 was included in our analysis due to previous publications suggesting a link between this gene and FTO [36].

Rask-Andersen et al. BMC Neuroscience 2011 12:117   doi:10.1186/1471-2202-12-117

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